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Abstract. Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine function, metabolism, immune function and other systems through its effects on the central nervous system and peripheral tissues. Leptin administration has been shown to restore metabolic and neuroendocrine abnormalities in individuals with leptin.
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Deprivation of nutrients or oxygen with subsequent energy depletion triggers adaptive processes such as metabolic reprogramming, epigenetic regulation of gene transcription, and autophagy, which allow cells to resist stress and to maintain their functions (Fig. 12.1A).Metabolic reprogramming is mediated by nutrient-sensing molecules such as AMPK, SIRT1, or mTORC1 (Fig. 12.1B).
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It is a common belief that slim people have a higher metabolism and overweight people have a slower metabolism. In fact, this is very rarely the case. This article will discuss the facts.
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Energy Metabolism. S.E. Cox, in Encyclopedia of Human Nutrition (Third Edition), 2013 Glycogen Metabolism. The red blood cells and the brain have an absolute requirement for glucose for energy metabolism.Glucose is absorbed from the intestines only for 2-3 h after a meal and therefore there must be another source of glucose to maintain a constant blood glucose level.
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